Gelatin modified with methacryloyl groups (GelMA)

Published : 02/25/2021 12:58:10

Hydrogels made of gelatin modified with methacryloyl groups (GelMA) are biocompatible, biodegradable, non-cytotoxic, and non-immunogenic [1]. GelMA-hydrogels possess tunable physicochemical properties, enabling flexibility to biofabricate a variety of tissues from  skeletal [2], respiratory [3], muscular [4], circulatory [5], digestive [6] and nervous [7] systems.

With our knowledge on gelatin we developed a proprietary technology that brings a much wider formulation window than any commercially available GelMA product. ClaroBGI800 is perfectly tailored for extrusion based 3D printing.

References

[1] K. Yue, G. Trujillo-de Santiago, M. M. Alvarez, A. Tamayol, N. Annabi, and A. Khademhosseini, “Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels,” Biomaterials, vol. 73, pp. 254–271, 2015, doi: https://doi.org/10.1016/j.biomaterials.2015.08.045.


[2] J. Liu, L. Li, H. Suo, M. Yan, J. Yin, and J. Fu, “3D printing of biomimetic multi-layered GelMA/nHA scaffold for osteochondral defect repair,” Mater. Des., vol. 171, p. 107708, 2019, doi: 10.1016/j.matdes.2019.107708.


[3] Z. Galliger, C. D. Vogt, and A. Panoskaltsis-Mortari, “3D bioprinting for lungs and hollow organs,” Transl. Res., vol. 211, pp. 19–34, Sep. 2019, doi: 10.1016/j.trsl.2019.05.001.


[4] G. H. Yang, W. Kim, J. Kim, and G. Kim, “A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting,” Theranostics, vol. 11, no. 1, pp. 48–63, Jan. 2021, doi: 10.7150/thno.50794.


[5] Y.-C. Chen et al., “Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels,” Adv. Funct. Mater., vol. 22, no. 10, pp. 2027–2039, May 2012, doi: 10.1002/adfm.201101662.


[6] M. Cuvellier et al., “3D culture of HepaRG cells in GelMa and its application to bioprinting of a multicellular hepatic model,” Biomaterials, vol. 269, p. 120611, 2021, doi: https://doi.org/10.1016/j.biomaterials.2020.120611.


[7] X. Zhou et al., “Three-Dimensional-Bioprinted Dopamine-Based Matrix for Promoting Neural Regeneration,” ACS Appl. Mater. Interfaces, vol. 10, no. 10, pp. 8993–9001, Mar. 2018, doi: 10.1021/acsami.7b18197.

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